LDLRAD1 polyclonal antibody

Product Specifications

Background

Low-density lipoprotein receptor class A domain-containing protein 1, belonging to the Low-density lipoprotein receptor class A domain-containing protein family.LDLRAD1 and LDLRAD2 function as recetor, LDLRAD3 may influence APP processing, resulting in a decrease in sAPP-alpha production and increased amyloidogenic P3 peptide production, LDLRAD3 functions as a negative regulator of TGF-beta signaling and thereby probably plays a role in cell proliferation, differentiation, apoptosis, motility, extracellular matrix production and immunosuppression. In the canonical TGF-beta pathway, ZFYVE9/SARA recruits the intracellular signal transducer and transcriptional modulators SMAD2 and SMAD3 to the TGF-beta receptor. Phosphorylated by the receptor, SMAD2 and SMAD3 then form a heteromeric complex with SMAD4 that translocates to the nucleus to regulate transcription. Through interaction with SMAD2 and SMAD3, LDLRAD4 may compete with ZFYVE9 and SMAD4 and prevent propagation of the intracellular signal.

CAS Number

9007-83-4

Structure Composition

Rabbit IgG, 1mg/ml in PBS with 0.02% sodium azide, 50% glycerol, pH7.2

Product Name Alternative

Low-density lipoprotein receptor class A domain-containing protein 1; LDLRAD1

Swiss Prot

Q5T700

Reactivity

Human, Mouse, Rat

Immunogen

Synthetic peptide, corresponding Human LDLRAD1.

Conjugation

Unconjugated

Applications

Dilution

WB: 1:500~1:1000

Purity

The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen and the purity is > 95% (by SDS-PAGE) .

Modification

Unmodification

Molecular Weight

~ 27 kDa

Storage Conditions

Store at 4°C short term. Aliquot and store at -20°C long term. Avoid freeze-thaw cycles.

Notes

For research use only, not for use in diagnostic procedure.

Specificity

LDLRAD1 polyclonal antibody detects endogenous levels of LDLRAD1 protein.

Applications Notes

Western blot (WB) analysis of LDLRAD1 polyclonal antibody at 1:500 dilution Lane1:Jurkat whole cell lysate (40ug) Lane2:A549 whole cell lysate (40ug) Lane3:Panc1 whole cell lysate (40ug) Lane4:MEF whole cell lysate (40ug) Lane5:PC12 whole cell lysate (40ug)