CDH22 polyclonal antibody
Product Specifications
Background
The cadherins are a family of Ca2+-dependent adhesion molecules that function to mediate cell-cell binding critical to the maintenance of structure and morphogenesis. Cadherins each contain a large extracellular domain at the N-terminus, which is characterized by a series of five homologous repeats, the most distal of which is thought to be responsible for binding specificity. Cadherin-22, also known as CDH22 or PB-cadherin (pituitary and brain cadherin), is an 828 amino acid single-pass type I membrane protein that, characteristic of cadherin proteins, contains five cadherin domains. Expressed predominately in brain, cadherin-22 functions as a Ca2+-dependent cell adhesion protein that is thought to play an important role in tissue formation and morphogenesis, specifically in neural cells during the development and maintenance of brain tissue.
Structure Composition
Rabbit IgG, 1mg/ml in PBS with 0.02% sodium azide, 50% glycerol, pH7.2
Product Name Alternative
Cadherin-22; Pituitary and brain cadherin; PB-cadherin
Swiss Prot
Q9UJ99
Reactivity
Human
Immunogen
Synthetic peptide, corresponding to amino acids 119-163 of Human CDH22
Conjugation
Unconjugated
Applications
WB
Dilution
WB: 1:500~1:1000
Purity
The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen and the purity is > 95% (by SDS-PAGE)
Modification
Unmodification
Molecular Weight
~ 89 kDa
Storage Conditions
Store at 4°C short term. Aliquot and store at -20°C long term. Avoid freeze-thaw cycles.
Notes
For research use only, not for use in diagnostic procedure.
Specificity
CDH22 polyclonal antibody detects endogenous levels of CDH22 protein.
Applications Notes
Western blot (WB) analysis of CDH22 polyclonal antibody at 1:500 dilution Lane1:A549 whole cell lysate (40ug) Lane2:L02 whole cell lysate (40ug) Lane3:PC3 whole cell lysate (40ug)
Host or Source
Rabbit
CAS Number
9007-83-4
Available Sizes
Curated Selection
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