CDH22 polyclonal antibody

Product Specifications

Background

The cadherins are a family of Ca2+-dependent adhesion molecules that function to mediate cell-cell binding critical to the maintenance of structure and morphogenesis. Cadherins each contain a large extracellular domain at the N-terminus, which is characterized by a series of five homologous repeats, the most distal of which is thought to be responsible for binding specificity. Cadherin-22, also known as CDH22 or PB-cadherin (pituitary and brain cadherin), is an 828 amino acid single-pass type I membrane protein that, characteristic of cadherin proteins, contains five cadherin domains. Expressed predominately in brain, cadherin-22 functions as a Ca2+-dependent cell adhesion protein that is thought to play an important role in tissue formation and morphogenesis, specifically in neural cells during the development and maintenance of brain tissue.

CAS Number

9007-83-4

Structure Composition

Rabbit IgG, 1mg/ml in PBS with 0.02% sodium azide, 50% glycerol, pH7.2

Product Name Alternative

Cadherin-22; Pituitary and brain cadherin; PB-cadherin

Swiss Prot

Q9UJ99

Reactivity

Human

Immunogen

Synthetic peptide, corresponding to amino acids 119-163 of Human CDH22

Conjugation

Unconjugated

Applications

Dilution

WB: 1:500~1:1000

Purity

The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen and the purity is > 95% (by SDS-PAGE)

Modification

Unmodification

Molecular Weight

~ 89 kDa

Storage Conditions

Store at 4°C short term. Aliquot and store at -20°C long term. Avoid freeze-thaw cycles.

Notes

For research use only, not for use in diagnostic procedure.

Specificity

CDH22 polyclonal antibody detects endogenous levels of CDH22 protein.

Applications Notes

Western blot (WB) analysis of CDH22 polyclonal antibody at 1:500 dilution Lane1:A549 whole cell lysate (40ug) Lane2:L02 whole cell lysate (40ug) Lane3:PC3 whole cell lysate (40ug)