ADM polyclonal antibody
Product Specifications
Background
Adrenomedullin (ADM), a vasodilator produced by most contractile cells, is characterized by persistent hypotensive activity. ADM is involved in the regulation of fluid and electrolyte homeostasis and the maintenance of cardiovascular functioning, and in hypertensive patients, the level of ADM in plasma is upregulated. Natriuresis is a common systemic manifestation of aneurysmal subarachnoid hemorrhage. ADM has strong natriuretic actions and ADM-induced natriuresis is caused by an increase in glomerular filtration rate and a decrease in distal tubular sodium reabsorption. ADM is present both in the periphery and brain, and this peptide can exert central effects such as decreasing food ingestion.
CAS Number
9007-83-4
Structure Composition
Rabbit IgG, 1mg/ml in PBS with 0.02% sodium azide, 50% glycerol, pH7.2
Product Name Alternative
ADM; AM; ProAM N-terminal 20 peptide; PAMP; ProAM-N2
Swiss Prot
P35318
Reactivity
Human, Mouse, Rat
Immunogen
Synthetic peptide, corresponding to amino acids 116-160 of Human ADM
Conjugation
Unconjugated
Applications
WB
Dilution
WB: 1:500~1:1000
Purity
The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen and the purity is > 95% (by SDS-PAGE)
Modification
Unmodification
Molecular Weight
~ 25 kDa
Storage Conditions
Store at 4°C short term. Aliquot and store at -20°C long term. Avoid freeze-thaw cycles.
Notes
For research use only, not for use in diagnostic procedure.
Specificity
ADM polyclonal antibody detects endogenous levels of ADM protein.
Applications Notes
Western blot (WB) analysis of ADM polyclonal antibody at 1:500 dilution Lane1:HCT116 whole cell lysate (40ug) Lane2:A549 whole cell lysate (40ug) Lane3:HEK293T whole cell lysate (40ug) Lane4:The Kidney lysate of Rat (40ug) Lane5:The Kidney lysate of Mouse (40ug)
Host or Source
Rabbit
Available Sizes
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