ZMYND8 polyclonal antibody

Members of the protein kinase C (PKC) family play a key regulatory role in a variety of cellular functions including cell growth and differentiation, gene expression, hormone secretion and membrane function. Receptor for activated C kinases, termed RACKs, are intracellular receptors for activated PKC that serve as anchors and may be involved in the activation-induced translocation of PKC. RACK7 (receptor for activated C kinase 7), also known as ZMYND8 (zinc finger MYND domain-containing protein 8), PRKCBP1 (protein kinase C (PKC) -binding protein 1) or PRO2893, is a widely expressed protein with predominant expression in pancreas, lung, placenta and brain. RACK7 contains one bromodomain, one PHD-type zinc finger, one MYND-type zinc finger and one PWWP domain. Via its C-terminus, RACK7 interacts with PKC ∫ and is believed to play a role in PKC signaling and function as a transcription regulator. In response to DNA damage, RACK7 is phosphorylated by ATM or ATR. In addition, multiple isoforms exist for RACK7.

The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen and the purity is > 95% (by SDS-PAGE)

Western blot (WB) analysis of ZMYND8 polyclonal antibody at 1:500 dilution Lane1:Jurkat whole cell lysate (40ug) Lane2:A549 whole cell lysate (40ug) Lane3:Panc1 whole cell lysate (40ug)