TAGAP polyclonal antibody

TAGAP (T-cell activation Rho GTPase-activating protein) is a 731 amino acid protein that contains one Rho-GAP domain and exists as 4 alternatively spliced isoforms. TAGAP mayfunction as a GTPase-activating protein and may play important roles during T-cell activation. The gene that encodes TAGAP contains approximately 10,685 bases andmapsto human chromosome 6q25.3. Making up nearly 6% of the human genome, chromosome 6 contains around 1,200 geneswithin 170million base pairs of sequence. Deletion of a portion of the q arm of chromosome 6 is as sociatedwith early onset intestinal cancer suggesting the presence of a cancer susceptibility locus. Porphyria cutanea tarda is as sociated with chromosome 6 through the HFE gene. Notably, the PARK2 gene, which is associated with Parkinson’s disease, and the genes encoding the major histocompatiblity complex proteins, are also located on chromosome 6. In addition, Stickler syndrome, hydroxylase deficiency andmaple syrup urine disease are associated with genes on chromosome 6, while a bipolar disorder susceptibility locus has been identified on the q arm of chromosome 6.

The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen and the purity is > 95% (by SDS-PAGE) .

Western blot (WB) analysis of TAGAP polyclonal antibody at 1:500 dilution Lane1:Hela whole cell lysate (40ug) Lane2:PC12 whole cell lysate (40ug) Lane3:RAW264.7 whole cell lysate (40ug) Lane4:MCF-7 whole cell lysate (40ug) Lane5:H9C2 whole cell lysate (40ug)