TNS3 polyclonal antibody

Product Specifications

Background

The Tensin (Tns) family of proteins is involved in the maintenance of cellular structure by anchoring actin filaments at the focal adhesion via F-actin binding and capping activities. Tns proteins also contain a Src homology 2 (SH2) domain and have the ability to be phosphorylated, suggesting a role in signal transduction cascades. These diverse characteristics indicate that Tns proteins may be important links between the cytoskeleton and signal transduction pathways. Tns3, also known as TEM6 or TENS1, localizes to the focal adhesions of the plasma membrane. It is predominantly expressed in thyroid and placenta but can also be found in heart, liver, brain, prostate, pancreas, kidney, lung, skeletal muscle and white blood cells. Tns3 is essential for proper growth and development, as suggested by growth retardation and death in a number of Tns3-/- mice.

CAS Number

9007-83-4

Structure Composition

Rabbit IgG, 1mg/ml in PBS with 0.02% sodium azide, 50% glycerol, pH7.2

Product Name Alternative

Tensin-3; Tensin-like SH2 domain-containing protein 1; Tumor endothelial marker 6; TNS3

Swiss Prot

Q68CZ2

Reactivity

Human, Mouse, Rat

Immunogen

Synthetic peptide, corresponding to amino acids 535-580 of Human TNS3.

Conjugation

Unconjugated

Applications

Dilution

WB: 1:500~1:1000

Purity

The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen and the purity is > 95% (by SDS-PAGE) .

Modification

Unmodification

Molecular Weight

~ 155 kDa

Storage Conditions

Store at 4°C short term. Aliquot and store at -20°C long term. Avoid freeze-thaw cycles.

Notes

For research use only, not for use in diagnostic procedure.

Specificity

TNS3 polyclonal antibody detects endogenous levels of TNS3 protein.

Applications Notes

Western blot (WB) analysis of TNS3 polyclonal antibody at 1:500 dilution Lane1:H9C2 whole cell lysate (40ug) Lane2:NIH-3T3 whole cell lysate (40ug) Lane3:DLD whole cell lysate (40ug)