TNS3 polyclonal antibody
Product Specifications
Background
The Tensin (Tns) family of proteins is involved in the maintenance of cellular structure by anchoring actin filaments at the focal adhesion via F-actin binding and capping activities. Tns proteins also contain a Src homology 2 (SH2) domain and have the ability to be phosphorylated, suggesting a role in signal transduction cascades. These diverse characteristics indicate that Tns proteins may be important links between the cytoskeleton and signal transduction pathways. Tns3, also known as TEM6 or TENS1, localizes to the focal adhesions of the plasma membrane. It is predominantly expressed in thyroid and placenta but can also be found in heart, liver, brain, prostate, pancreas, kidney, lung, skeletal muscle and white blood cells. Tns3 is essential for proper growth and development, as suggested by growth retardation and death in a number of Tns3-/- mice.
CAS Number
9007-83-4
Structure Composition
Rabbit IgG, 1mg/ml in PBS with 0.02% sodium azide, 50% glycerol, pH7.2
Product Name Alternative
Tensin-3; Tensin-like SH2 domain-containing protein 1; Tumor endothelial marker 6; TNS3
Swiss Prot
Q68CZ2
Reactivity
Human, Mouse, Rat
Immunogen
Synthetic peptide, corresponding to amino acids 535-580 of Human TNS3.
Conjugation
Unconjugated
Applications
WB
Dilution
WB: 1:500~1:1000
Purity
The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen and the purity is > 95% (by SDS-PAGE) .
Modification
Unmodification
Molecular Weight
~ 155 kDa
Storage Conditions
Store at 4°C short term. Aliquot and store at -20°C long term. Avoid freeze-thaw cycles.
Notes
For research use only, not for use in diagnostic procedure.
Specificity
TNS3 polyclonal antibody detects endogenous levels of TNS3 protein.
Applications Notes
Western blot (WB) analysis of TNS3 polyclonal antibody at 1:500 dilution Lane1:H9C2 whole cell lysate (40ug) Lane2:NIH-3T3 whole cell lysate (40ug) Lane3:DLD whole cell lysate (40ug)
Host or Source
Rabbit
Available Sizes
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