TEAD2 polyclonal antibody
Product Specifications
Background
The transcriptional enhancer factor (TEF) /TEAD family includes TEF-1, TEF-3, TEF-4 and TEF-5. These proteins share a highly conserved 68-amino acid TEA/ATTS DNA-binding domain, which binds to SV40 GT-IIC (GGAATG), SphI (AGTATG), SphII (AGCATG), and muscle-specific M-CAT (GGTATG) enhansons. TEFs are differentially expressed in human cultured cell lines and mouse embryonic and extra-embryonic tissues. Specifically, TEF-4 is strongly coexpressed with TEF-1 in mouse mitotic neuroblasts and is also detected in the gut and the nephrogenic region of the kidney. TEF-4 associates with the powerful transcriptional coactivator YAP65 to mediate mitogenic signals. In addition, TEF-4 promotes the activation of the CTP:phosphocholine cytidylyltransferase (CCT) alpha protein, which is the rate-limiting enzyme of phosphatidylcholine biosynthesis, by enhancing the transcriptional activity of Ets-1.
CAS Number
9007-83-4
Structure Composition
Rabbit IgG, 1mg/ml in PBS with 0.02% sodium azide, 50% glycerol, pH7.2
Product Name Alternative
Transcriptional enhancer factor TEF-4; TEA domain family member 2; TEAD-2; TEAD2; TEF4
Swiss Prot
Q15562
Reactivity
Human, Mouse, Rat
Immunogen
Synthetic peptide, corresponding to amino acids 61-106 of Human TEAD2.
Conjugation
Unconjugated
Related Pathways
Hippo Signaling
Applications
WB
Dilution
WB:1:500~1:1000
Purity
The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen and the purity is > 95% (by SDS-PAGE) .
Modification
Unmodification
Molecular Weight
~ 49 kDa
Storage Conditions
Store at 4°C short term. Aliquot and store at -20°C long term. Avoid freeze-thaw cycles.
Notes
For research use only, not for use in diagnostic procedure.
Specificity
TEAD2 polyclonal antibody detects endogenous levels of TEAD2 protein.
Applications Notes
Western blot (WB) analysis of TEAD2 polyclonal antibody at 1:500 dilution Lane1:HEH293T whole cell lysate (40ug) Lane2:RAW264.7 whole cell lysat (40ug) Lane3:H9C2 whole cell lysate (40ug)
Host or Source
Rabbit
Available Sizes
Frequently Asked Questions
More Discoveries
Explore Other Products
Browse additional items from our catalog
