Claudin-9 polyclonal antibody
Product Specifications
Background
The claudin superfamily consists of many structurally related proteins in humans (1) . These proteins are important structural and functional components of tight junctions in paracellular transport (1,2) . Claudins are located in both epithelial and endothelial cells in all tight junction-bearing tissues (1) . Three classes of proteins are known to localize to tight junctions, including the claudins, Occludin and junction adhesion molecule (3) . Claudins, which consist of four transmembrane domains and two extracellular loops make up tight junction strands (4) . Claudin expression is often highly restricted to specfic regions of different tissues and may have an important role in transcellular transport through tight junctions (5) . Claudin-9 is highly similar to claudin-3 (also designated clostridium perfringens enterotoxin receptor) (6) . Claudin-9 is expressed in simian virus (SV) 40-immortalized human corneal epithelial (THCE) cells (7) . The human claudin-9 gene maps to chromosome 16p13.3 (6) .
CAS Number
9007-83-4
Structure Composition
Rabbit IgG, 1mg/ml in PBS with 0.02% sodium azide, 50% glycerol, pH7.2
Product Name Alternative
Claudin-9; CLDN9
Swiss Prot
O95484
Reactivity
Human, Mouse, Rat
Immunogen
A synthetic peptide corresponding to residues in Human Claudin-9.
Conjugation
Unconjugated
Applications
WB
Dilution
WB: 1:500~1:1000
Purity
The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen and the purity is > 95% (by SDS-PAGE) .
Modification
Unmodification
Molecular Weight
~ 23 kDa
Storage Conditions
Store at 4°C short term. Aliquot and store at -26°C long term. Avoid freeze-thaw cycles.
Notes
For research use only, not for use in diagnostic procedure.
Specificity
Claudin-9 polyclonal antibody detects endogenous levels of Claudin-9 protein.
Applications Notes
Western blot (WB) analysis of Claudin-9 polyclonal antibody at 1:500 dilution Line1:Hela whole cell lysate Line2:H9C2 whole cell lysate Line3:Raw264.7 whole cell lysate
Host or Source
Rabbit
Available Sizes
Curated Selection
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