POLG2 polyclonal antibody

DNA replication, recombination and repair, all of which are necessary for genomic stability, require the presence of exonucleases. In DNA replication, these enzymes are involved in the processing of Okazaki fragments, whereas in DNA repair, they function to excise damaged DNA fragments and correct recombinational mismatches. These exonucleases include the family of DNA polymerases. DNA pol γ2 (polymerase (DNA directed), gamma 2, accessory subunit), also known as mitochondrial DNA polymerase accessory subunit, POLB, HP55, PEOA4, POLGB, MTPOLB, POLG-BETA or POLG2, is a 485 amino acid subunit of mitochondrial DNA pol γ. DNA pol γ2 enhances DNA binding and promotes processive DNA synthesis. Defects in the gene encoding DNA pol γ2 are the cause of PEOA4 (progressive external ophthalmoplegia with mitochondrial DNA deletions autosomal dominant type 4) .

The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen and the purity is > 95% (by SDS-PAGE) .

Western blot (WB) analysis of POLG2 polyclonal antibody at 1:500 dilution Lane1:A549 whole cell lysate Lane2:Hela whole cell lysate Lane3:H9C2 whole cell lysate Lane4:SP20 whole cell lysate