CYP26C1 polyclonal antibody
Product Specifications
Background
Cytochrome P450 proteins are heme-thiolate monooxygenases that mediate NADPH-dependent electron transport and function to oxidize a variety of structurally unrelated compounds, including steroids, fatty acids and xenobiotics. Specifically, cytochrome P450s are responsible for metabolizing arachidonic acid to hydroxyeicosatetraenoic acid (a regulator of blood pressure) and epoxyeicosatrienoic acid (a molecule involved in signaling events) . CYP26C1 (cytochrome P450, family 26, subfamily C, polypeptide 1) is a 522 amino acid single-pass membrane protein expressed in most tissues at very low levels. Belonging to the cytochrome P450 family, CYP26C1 uses heme groups as cofactors and is induced by retinoic acid. CYP26C1 participates in the retinoic metabolism and acts on retinoids, including all-trans-retinoic acid (RA) and its stereoisomer, 9-cis-RA.
CAS Number
9007-83-4
Structure Composition
Rabbit IgG, 1mg/ml in PBS with 0.02% sodium azide, 50% glycerol, pH7.2
Product Name Alternative
Cytochrome P450 26C1 (EC:1.14.-.-) ; CYP26C1
Swiss Prot
Q6V0L0
Reactivity
Human, Mouse, Rat
Immunogen
A synthetic peptide corresponding to residues in Human CYP26C1.
Conjugation
Unconjugated
Applications
WB
Dilution
WB: 1:500~1:1000
Purity
The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen and the purity is > 95% (by SDS-PAGE) .
Modification
Unmodification
Molecular Weight
~ 57 kDa
Storage Conditions
Store at 4°C short term. Aliquot and store at -20°C long term. Avoid freeze-thaw cycles.
Notes
For research use only, not for use in diagnostic procedure.
Specificity
CYP26C1 polyclonal antibody detects endogenous levels of CYP26C1 protein.
Applications Notes
Western blot (WB) analysis of CYP26C1 polyclonal antibody at 1:500 dilution Lane1:HEK293T whole cell lysate Lane2:RAW264.7 whole cell lysate Lane3:H9C2 whole cell lysate
Host or Source
Rabbit
Available Sizes
Frequently Asked Questions
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