MAGEA9 polyclonal antibody

The melanoma-associated antigen (MAGE) family consists of a number of antigens recognized by cytotoxic T lymphocytes. The MAGE genes were initially isolated from different kinds of tumors and, based on their virtually exclusive tumor-specific expression in adult tissues, they have been used as targets for cancer immunotherapy. MAGE genes encode for tumor-rejection antigens and are expressed in tumors of different histologic types as well as in normal testis and placenta. MAGE-A9 (melanoma-associated antigen 9), also known as MAGE9 or CT1.9 (cancer/testis antigen 1.9), is a 315 amino acid protein that contains one MAGE domain. Like most MAGE family members, MAGE-A9 is expressed in several types of tumors, including lung cancer, breast cancer and melanoma, and is thought to play an important role in tumor progression and transformation. Additionally, MAGE-A9 may be involved in embryonic development.

The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen and the purity is > 95% (by SDS-PAGE) .

Western blot (WB) analysis of MAGEA9 polyclonal antibody at 1:500 dilution Lane1:HEK293T whole cell lysate Lane2:RAW264.7 whole cell lysate Lane3:H9C2 whole cell lysate