TNFSF4 polyclonal antibody

The Ox40 ligand, Ox40L (also designated gp34), is a type II membrane protein, due to the absence of a signal peptide. Ox40L, a member of the tumor necrosis factor (TNF) superfamily, is a costimulatory molecule involved in dendritic cell:T cell interactions, T cell homing and B cell activation. Engagement of Ox40L with its receptor, Ox40, delivers a strong costimulatory signal to effector T cells. Ox40L is found preferentially on activated B cells and its receptor, Ox40, is a member of the tumor necrosis factor receptor (TNFR) family that is expressed on activated T cells. Ox40L plays a critical role in antigen-specific T cell responses in vivo and in both the priming and effector phases of T cell activation when expressed on antigen-presenting cells (APCs) .

Tumor necrosis factor ligand superfamily member 4; Glycoprotein Gp34; OX40 ligand; OX40L; TAX transcriptionally-activated glycoprotein 1; CD252; TNFSF4; TXGP1

The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen and the purity is > 95% (by SDS-PAGE) .

Western blot (WB) analysis of TNFSF4 polyclonal antibody at 1:500 dilution Lane1:A549 whole cell lysate Lane2:H9C2 whole cell lysate Lane3:SP20 whole cell lysate