ZNF462 polyclonal antibody

Zinc-finger proteins contain DNA-binding domains and have a wide variety of functions, most of which encompass some form of transcriptional activation or repression. The majority of zinc-finger proteins contain a Krüppel-type DNA binding domain and a KRAB domain, which is thought to interact with KAP1, thereby recruiting histone modifying proteins. ZNF462 (zinc finger protein 462) is a 2,506 amino acid protein that localizes to nucleus and is subject to posttranslational phosphorylation upon DNA damage, possibly by ATM or ATR.Containing twenty-seven C2H2-type zinc finger motifs and existing as multiple alternatively spliced isoforms, ZNF462 is encoded by a gene located on human chromosome 9q31.2. Chromosome 9 consists of about 145 million bases, 4% of the human genome and encodes nearly 900 genes. Hereditary hemorrhagic telangiectasia, which is characterized by harmful vascular defects, and Familial dysautonomia, are both associated with chromosome 9.Notably, chromosome 9 encompasses the largest interferon family gene cluster.

The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen and the purity is > 95% (by SDS-PAGE) .