PSG3 polyclonal antibody

Product Specifications

Background

The pregnancy-specific glycoproteins (PSGs) are a group of closely related secreted glycoproteins that are highly expressed in fetal placental syncytiotrophoblast cells. Members of the PSG protein family share a characteristic N-terminal domain that is homologous to the immunoglobulin variable region. PSGs become detectable in serum during the first two to three weeks of pregnancy and increase as the pregnancy progresses, eventually representing the most abundant fetal protein in the maternal blood at term. PSGs function to stimulate secretion of TH2-type cytokines from monocytes, and they may also modulate the maternal immune system during pregnancy, thereby protecting the semi-allotypic fetus from rejection. Eleven human PSG proteins (PSG1-PSG11) have been described.

CAS Number

9007-83-4

Structure Composition

Rabbit IgG, 1mg/ml in PBS with 0.02% sodium azide, 50% glycerol, pH7.2

Product Name Alternative

Pregnancy-specific beta-1-glycoprotein 3; PS-beta-G-3; PSBG-3; Pregnancy-specific glycoprotein 3; Carcinoembryonic antigen SG5

Swiss Prot

Q16557

Reactivity

Human, Mouse, Rat

Immunogen

A synthetic peptide corresponding to residues in Human PSG3

Conjugation

Unconjugated

Applications

Dilution

WB: 1:500~1:1000

Purity

The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen and the purity is > 95% (by SDS-PAGE) .

Modification

Unmodification

Molecular Weight

~ 48 kDa

Storage Conditions

Store at 4°C short term. Aliquot and store at -20°C long term. Avoid freeze-thaw cycles.

Notes

For research use only, not for use in diagnostic procedure.

Specificity

PSG3 polyclonal antibody detects endogenous levels of PSG3 protein.

Applications Notes

Western blot (WB) analysis of PSG3 polyclonal antibody at 1:500 dilution Lane1:HEK293Twhole cell lysate Lane2:Raw264.7 whole cell lysate Lane3:PC12 whole cell lysate