PROK1 polyclonal antibody

Endocrine gland-derived vascular endothelial growth factor (EG-VEGF) induces proliferation, migration and fenestration in capillary endothelialcells derived from endocrine glands. EG-VEGF possesses a HIF-1 binding site; its expression isinduced by hypoxia and restricted to the steroidogenic glands (ovary, testis, adrenal and placenta) . EG-VEGF expression is often complementary to the expression of VEGF, suggesting that these moleculesfunction in a coordinatedmanner. EG-VEGFis an example of a class of highly specificmitogensthat act to regulate proliferation and differentiation of the vascular endothelium in a tissue-specific manner. EG-VEGFis expressed largely in one type of tissue and actsselectively on one type of endothelium. EG-VEGF, possiblythrough binding to a G protein-coupled receptor, resultsin the activation ofMAPK p44/42 and phosphatidylinositol 3-kinase signaling pathways, leading to proliferation, migration and survival of responsive endothelialcells.

The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen and the purity is > 95% (by SDS-PAGE) .

Western blot (WB) analysis of PROK1 polyclonal antibody at 1:500 dilution Lane1:HEK293T whole cell lysate Lane2:Raw264.7 whole cell lysate Lane3:PC12 whole cell lysate