QSER1 polyclonal antibody

QSER1 (glutamine and serine-rich protein 1) is a 1,735 amino acid protein that is phosphorylated upon DNA damage, probably by Atm or ATR. A single nucleotide polymorphism (SNP) that is nearly equidistant between the genes QSER1 and PRRG4 on chromosome 11, at just under 20 kb from each, has been suspected of association with Parkinson disease. Existing as two alternatively spliced isoforms, the QSER1 gene is conserved in chimpanzee, canine, bovine, mouse, rat, chicken and zebrafish, and maps to human chromosome 11p13. With approximately 135 million base pairs and 1,400 genes, chromosome 11 makes up around 4% of human genomic DNA and is considered a gene and disease association dense chromosome. Jervell and Lange-Nielsen syndrome, Jacobsen syndrome, Niemann-Pick disease, hereditary angioedema and Smith-Lemli-Opitz syndrome are also associated with defects in chromosome 11.

The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen and the purity is > 95% (by SDS-PAGE) .

Western blot (WB) analysis of QSER1 polyclonal antibody at 1:500 dilution Lane1:A549 whole cell lysate Lane2:Raw264.7 whole cell lysate Lane3:PC12 whole cell lysate