CD248 polyclonal antibody
Product Specifications
Background
Tumor endothelial marker 1 (TEM1/endosialin) is a heavily glycosylated, type I transmembrane C-type lectin-like receptor of the Ras superfamily expressed in the vascular endothelium and on fibroblast-like cells in developing organs. Expression of TEM1 largely disappears in adulthood. TEM1 is structurally related to thrombomodulin and complement receptor C1qRp. It consists of three EGF-like domains, a C-type lectin domain and a Sushi domain. TEM1 is highly upregulated in tumor endothelium and is known to function in tumor growth and progression. For this reason TEM1 is a major target in anti-angiogenic tumor therapy. TEM1 may be responsible for concentrating liposomes on the surface of target cells and promoting their fusion with the cell membrane.
CAS Number
9007-83-4
Structure Composition
Rabbit IgG, 1mg/ml in PBS with 0.02% sodium azide, 50% glycerol, pH7.2
Product Name Alternative
Endosialin; Tumor endothelial marker 1; CD164L1; TEM1
Swiss Prot
Q9HCU0
Reactivity
Human, Mouse, Rat
Immunogen
A synthetic peptide corresponding to residues in Human CD248.
Conjugation
Unconjugated
Applications
WB
Dilution
WB: 1:500~1:1000
Purity
The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen and the purity is > 95% (by SDS-PAGE) .
Modification
Unmodification
Molecular Weight
~ 50, 80 kDa
Storage Conditions
Store at 4°C short term. Aliquot and store at -20°C long term. Avoid freeze-thaw cycles.
Notes
For research use only, not for use in diagnostic procedure.
Specificity
CD248 polyclonal antibody detects endogenous levels of Endosialin protein.
Applications Notes
Western blot (WB) analysis of CD248 polyclonal antibody at 1:500 dilution Lane1:HEK293T whole cell lysate Lane2:NIH-3T3 whole cell lysate Lane3:H9C2 whole clel lysate
Host or Source
Rabbit
Available Sizes
Frequently Asked Questions
More Discoveries
Explore Other Products
Browse additional items from our catalog
T9167-03 100 µg
TUSC2 (Tumor Suppressor Candidate 2, C3orf11, FUS1, Fus-1 Protein, Fusion 1 Protein, LGCC, PAP, PDAP2, PDGFA-associated Protein 2, Tumor Suppressor Candidate 2)
Sign In for Pricing
View Details 
