TGFα polyclonal antibody
Product Specifications
Background
Transforming growth factor-α (TGFα) is an acid- and heat-stable 50 amino acid protein originally found in rodents and humans. TGFα is 33% homologous at the amino acid level to epidermal growth factor (EGF) . TGFα binds to the EGF receptor, mediates tyrosine phosphorylation of the receptor and promotes anchorage-independent growth of normal rat fibroblasts in soft agar in the presence of transforming growth factor-b. TGFα is secreted by a variety of transformed cells and tumors, embryonic cells and some normal adult cells. TGFα bioactivity has been found in the urine of cancer patients. It has been suggested that it may act as an autocrine growth factor for the induction or maintenance of malignancy.
Structure Composition
Rabbit IgG, 1mg/ml in PBS with 0.02% sodium azide, 50% glycerol, pH7.2
Product Name Alternative
Protransforming growth factor alpha; Transforming growth factor alpha; TGF-alpha; EGF-like TGF; ETGF; TGF type 1; TGFA; TGF α
Swiss Prot
P01135
Reactivity
Human, Mouse, Rat
Immunogen
A synthetic peptide corresponding to residues in Human TGFα.
Conjugation
Unconjugated
Related Pathways
TGFβ Smad signaling
Applications
WB
Dilution
WB: 1:500~1:1000
Purity
The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen and the purity is > 95% (by SDS-PAGE) .
Modification
Unmodification
Molecular Weight
~ 17 kDa
Storage Conditions
Store at 4°C short term. Aliquot and store at -20°C long term. Avoid freeze-thaw cycles.
Notes
For research use only, not for use in diagnostic procedure.
Specificity
TGFα polyclonal antibody detects endogenous levels of TGFα protein.
Applications Notes
Western blot (WB) analysis of TGFα polyclonal antibody at 1:500 dilution Lane1:THP-1 whole cell lysate Lane2:Mouse brain tissue lysate Lane3:Rat brain tissue lysate
Host or Source
Rabbit
CAS Number
9007-83-4
Available Sizes
Curated Selection
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