EFTUD2 polyclonal antibody

Product Specifications

Background

Spliceosomes are multi-protein complexes that are composed of snRNPs (small nuclear ribonucleoproteins) and a variety of associated protein factors, all of which work in concert to regulate the splicing of pre-mRNA. Snrp116, also known as EFTUD2 (elongation factor Tu GTP binding domain containing 2) or Snu114, is a 972 amino acid protein that localizes to the nucleus and belongs to the GTP-binding elongation factor family. Existing as a component of the multi-protein U5 snRNP spliceosome complex, Snrp116 plays an important role in pre-mRNA splicing, as well as in the recycling of spliceosomal snRNPs. The gene encoding Snrp116 maps to human chromosome 17, which comprises over 2.5% of the human genome and encodes over 1,200 genes.

CAS Number

9007-83-4

Structure Composition

Rabbit IgG, 1mg/ml in PBS with 0.02% sodium azide, 50% glycerol, pH7.2

Product Name Alternative

116 kDa U5 small nuclear ribonucleoprotein component; Elongation factor Tu GTP-binding domain-containing protein 2; SNU114 homolog; Hsnu114; U5 snRNP-specific protein, 116 kDa; U5-116 kDa; KIAA0031; SNRP116

Swiss Prot

Q15029

Reactivity

Human, Mouse, Rat

Immunogen

Synthetic peptide, corresponding to amino acids 371-416 of Human EFTUD2.

Conjugation

Unconjugated

Applications

WB IHC ICC

Dilution

WB: 1:500~1:1000 IHC: 1:50~1:200 ICC: 1:50~1:200

Purity

The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen and the purity is > 95% (by SDS-PAGE) .