Na+ CP type IIβ polyclonal antibody

Product Specifications

Background

Voltage-gated sodium channels are selective ion channels that regulate the permeability of sodium ions in excitable cells. During the propagation of an action potential, sodium channels allow an influx of sodium ions, which rapidly depolarizes the cell. Na+ CP type IIβ (sodium channel, voltage-gated, typeII, β), also known as SCN2B, is a 215 amino acid single-pass type I membrane protein that plays a critical role in the expression and assembly of the heterotrimeric complex of the sodium channel and interacts with Tenascin-R to influence the clustering and regulation of sodium channels at nodes of Ranvier. Expressed specifically in brain, Na+ CP type IIβ contains one Ig-like C2-type (immunoglobulin-like) domain and is encoded by a gene that maps to human chromosome 11q23.3 and mouse chromosome 9 A5.2.

CAS Number

9007-83-4

Structure Composition

Rabbit IgG, 1mg/ml in PBS with 0.02% sodium azide, 50% glycerol, pH7.2

Product Name Alternative

Sodium channel subunit beta-2; SCN2B; ORF Names: UNQ326/PRO386; Na+ CP typeIIβ

Swiss Prot

O60939

Reactivity

Human, Mouse, Rat

Immunogen

Synthetic peptide, corresponding to amino acids 114-159 of Human Na+ CP type IIβ.

Conjugation

Unconjugated

Applications

Dilution

WB: 1:500~1:1000

Purity

The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen and the purity is > 95% (by SDS-PAGE) .

Modification

Unmodification

Molecular Weight

~ 24 kDa

Storage Conditions

Store at 4°C short term. Aliquot and store at -20°C long term. Avoid freeze-thaw cycles.

Notes

For research use only, not for use in diagnostic procedure.

Specificity

Na+ CP type IIβ polyclonal antibody detects endogenous levels of Na+ CP type IIβ protein.

Applications Notes

Western blot (WB) analysis of Na+ CP type IIβ polyclonal antibody at 1:500 dilution Lane1:HEK29T cell lysate Lane2:Raw264.7 cell lysate Lane3:Rat liver tissue lysate