GPR171 polyclonal antibody

G protein-coupled receptors (GPRs), also known as seven transmembrane receptors, heptahelical receptors or 7TM receptors, comprise a superfamily of proteins that play a role in many different stimulus-response pathways. GPR signaling is an evolutionarily ancient mechanism used by all eukaryotes to sense environmental stimuli and mediate cell-cell communication. G protein-coupled receptors translate extracellular signals into intracellular signals (G protein activation) and they respond to a variety of signaling molecules, such as hormones and neurotransmitters. G protein-coupled receptors provide attractive targets for drug therapy due to the sheer size and diversity of ligands within this receptor family. GPR171, also designated H963, is a 319 amino acid protein that is structurally related to the purinergic receptors P2Y12, P2Y13 and P2Y14.

The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen and the purity is > 95% (by SDS-PAGE) .

Western blot (WB) analysis of GPR171 polyclonal antibody at 1:500 dilution Lane1:HEK293T cell lysate Lane2:Mouse liver tissue lysate Lane3:Rat liver tissue lysate