GALK1 polyclonal antibody

Product Specifications

Background

Galactose kinase (GALK1), also often designated galactokinase, is important in the first step of the galactose metabolism pathway. GALK1, which belongs to the GHMP kinase family of proteins, is a crucial enzyme for galactose metabolism. Defects in the gene encoding for galactose kinase, GALK1, can cause galactosemia II, an autosomal recessive disorder characterized by congenital cataracts during infancy, often within the first two weeks of life. In the adult population it can cause presenile cataracts that are secondary to accumulation of galactitol in the lens of the eye.

CAS Number

9007-83-4

Structure Composition

Rabbit IgG, 1mg/ml in PBS with 0.02% sodium azide, 50% glycerol, pH7.2

Product Name Alternative

Galactokinase; Galactose kinase; GALK1; GALK

Swiss Prot

P51570

Reactivity

Human, Mouse, Rat

Immunogen

Synthetic peptide, corresponding to amino acids 4-49 of Human GALK1.

Conjugation

Unconjugated

Applications

WB IHC ICC

Dilution

WB: 1:500~1:1000 IHC: 1:50~1:200 ICC: 1:50~1:200

Purity

The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen and the purity is > 95% (by SDS-PAGE) .

Modification

Unmodification

Molecular Weight

~ 42 kDa

Storage Conditions

Store at 4°C short term. Aliquot and store at -20°C long term. Avoid freeze-thaw cycles.

Notes

For research use only, not for use in diagnostic procedure.

Specificity

GALK1 polyclonal antibody detects endogenous levels of GALK1 protein.

Applications Notes

Western blot (WB) analysis of GALK1 polyclonal antibody at 1:500 dilution Lane1:HEK293T cell lysate Lane2:sp2/0 cell lysate Lane3:Rat liver tissue lysate