Caspase 5 p10 polyclonal antibody
Product Specifications
Background
Caspase-5 (also designated ICErel-III, TY, ICH-3 and caspase-12 in mouse), can cleave its own precursor, an activity that requires the cysteine 245 residue. Frameshift mutations in caspase-5 have been identified in MMP tumors of the endometrium, colon, and stomach, indicating the caspase-5 may be a new target gene in the microsatellite mutator pathway for cancer. The human caspase 5 gene maps to chromosome 11q22.2-q22.3 and encodes a protein whose expression is barely detectable in most tissues except brain, with highest expression levels being found in lung, liver and skeletal muscle.
CAS Number
9007-83-4
Structure Composition
Rabbit IgG, 1mg/ml in PBS with 0.02% sodium azide, 50% glycerol, pH7.2
Product Name Alternative
Caspase-5; CASP-5; ICE (rel) -III; Protease ICH-3; Protease TY; Caspase-5 subunit p10; CASP5; ICH3; Caspase5
Swiss Prot
P51878
Reactivity
Human, Mouse, Rat
Immunogen
Synthetic peptide, corresponding to amino acids 341-386 of Human Caspase-5.
Conjugation
Unconjugated
Related Pathways
Inflammasonme Signaling, Necrotic Cell Death
Applications
WB
Dilution
WB: 1:500~1:1000
Purity
The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen and the purity is > 95% (by SDS-PAGE) .
Modification
Unmodification
Molecular Weight
~ 10, 48 kDa
Storage Conditions
Store at 4°C short term. Aliquot and store at -20°C long term. Avoid freeze-thaw cycles.
Notes
For research use only, not for use in diagnostic procedure.
Specificity
Caspase 5 p10 polyclonal antibody recognizes endogenous levels of total caspase-5 protein and the p10 subunit of mature caspase-5.
Applications Notes
Western blot (WB) analysis of Caspase 5 p10 polyclonal antibody at 1:500 dilution Lane1:Jurkat cell lysate Lane2:Mouse liver tissue lysate Lane3:Rat liver tissue lysate
Host or Source
Rabbit
Available Sizes
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