SLC25A12 polyclonal antibody

Calcium signaling in mitochondria is important in order for it to function in response to a variety of extracellular stimuli. Signaling begins with Ca (2+) entry in mitochondria via the Ca (2+) uniporter followed by Ca (2+) activation of three dehydrogenases in the mitochondrial matrix. ARALAR, the neuronal Ca (2+) -binding mitochondrial aspartate-glutamate carrier, has Ca (2+) binding domains facing the extramitochondrial space and functions in the malate-aspartate NADH shuttle (MAS) . ARALAR is encoded by the SLC25A12 gene and is expressed in brain and skeletal muscle. ARALAR is required for the synthesis of brain aspartate and N-acetylaspartatemay and plays a role in myelin formation. It is also essential for the transmission of small Ca (2+) signals to mitochondria via an increase in mitochondrial NADH. In addition, ARALAR is implicated in conferring susceptibility to schizophrenia.

The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen and the purity is > 95% (by SDS-PAGE) .