ATM (I1987) polyclonal antibody
Product Specifications
Background
The phosphatidylinositol kinase (PIK) family members fall into two distinct subgroups. The first subgroup contains proteins such as the PI 3- and PI 4-kinases and the second group comprises the PIK-related kinases. The PIK-related kinases include Atm, DNA-PKCS and FRAP. These proteins have in common a region of homology at their carboxy-termini that is not present in the PI 3- and PI 4-kinases. The Atm gene is mutated in the autosomal recessive disorder ataxia telangiectasia (AT) that is characterized by cerebellar degeneration (ataxia) and the appearance of dilated blood vessels (telangiec-tases) in the conjunctivae of the eyes. AT cells are hypersensitive to ionizing radiation, impaired in mediating the inhibition of DNA synthesis and display delays in p53 induction.
CAS Number
9007-83-4
Structure Composition
Rabbit IgG, 1mg/ml in PBS with 0.02% sodium azide, 50% glycerol, pH7.2
Product Name Alternative
A-T mutated; A-T mutated homolog; AT complementation group A; AT complementation group C; AT complementation group D; AT complementation group E; AT mutated; AT protein; AT1; AT1; ATA; Ataxia telangiectasia gene mutated in human beings; Ataxia telangiectasia mutated; Ataxia telangiectasia mutated gene; Ataxia telangiectasia mutated homolog (human) ; Ataxia telangiectasia mutated homolog; ATC; ATD; ATDC; ATE; ATM; ATM; DKFZp781A0353; Human phosphatidylinositol 3 kinase homolog; MGC74674; OTT
Swiss Prot
Q13315
Reactivity
Human
Immunogen
Synthetic peptide, corresponding to amino acids 1957-2006 of Human ATM.
Conjugation
Unconjugated
Related Pathways
Cell Cycle Control G1 S Checkpoint, Cell Cycle G2 M DNA Damage Signaling Pathway, Mitochondrial Control of Apoptosis
Applications
WB IHC
Dilution
IHC: 1:50~1:200
Purity
The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen and the purity is > 95% (by SDS-PAGE) .
Modification
Unmodification
Molecular Weight
~ 350 kDa
Storage Conditions
Store at 4°C short term. Aliquot and store at -20°C long term. Avoid freeze-thaw cycles.
Notes
For research use only, not for use in diagnostic procedure.
Specificity
ATM (I1987) polyclonal antibody detects endogenous levels of ATM protein.
Applications Notes
Western blot (WB) analysis of ATM (I1987) pAb at 1:500 dilution Lane1:HEK293T whole cell lysate (40ug) Lane2:L02 whole cell lysate (40ug) Lane3:H1792 whole cell lysate (40ug)
Host or Source
Rabbit
Available Sizes
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