Crk2 (phospho-Try221) polyclonal antibody
Product Specifications
Background
Crk I and Crk II are encoded by the same gene, which undergoes alternative splicing to yield these two proteins, but differ in their biological activities. Crk II has less transforming activity than Crk I, although both Crk I and Crk II bind to many tyrosine-phosphorylated proteins that bind to GRB2. In addition, Crk II becomes rapidly tyrosine-phosphorylated in response to stimulation with insulin-like growth factor I (IGF-I) and might be involved in the IGF-I receptor signalling pathway.
CAS Number
9007-83-4
Structure Composition
Rabbit IgG, 1mg/ml in PBS with 0.02% sodium azide, 50% glycerol, pH7.2
Product Name Alternative
Adapter molecule crk; Proto-oncogene c-Crk; p38 CRK; CRK; CRKII
Swiss Prot
P46108
Reactivity
Human, Mouse, Rat
Immunogen
Synthetic phosphopeptide derived from human Crk2 around the phosphorylation site of Tyrosine 221.
Conjugation
Unconjugated
Applications
IHC
Dilution
IHC: 1:50~1:200
Purity
The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen and the purity is > 95% (by SDS-PAGE) .
Modification
Phosphorylation
Molecular Weight
~ 42 kDa
Storage Conditions
Store at 4°C short term. Aliquot and store at -20°C long term. Avoid freeze-thaw cycles.
Notes
For research use only, not for use in diagnostic procedure.
Specificity
P-Crk2 (Try221) polyclonal antibody detects endogenous levels of Crk2 protein only when phosphorylated at Try221.
Host or Source
Rabbit
Available Sizes
Frequently Asked Questions
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