Catenin-β (phospho-T41/S45) polyclonal antibody
Product Specifications
Background
β-Catenin is a key downstream effector in the Wnt signaling pathway. It is implicated in two major biological processes in vertebrates: early embryonic development and tumorigenesis. CK1 phosphorylates β-catenin at Ser45. This phosphorylation event primes β-catenin for subsequent phosphorylation by GSK-3β. GSK-3β destabilizes β-catenin by phosphorylating it at Ser33, Ser37, and Thr41. Mutations at these sites result in the stabilization of β-catenin protein levels and have been found in many tumor cell lines.
CAS Number
9007-83-4
Structure Composition
Rabbit IgG, 1mg/ml in PBS with 0.02% sodium azide, 50% glycerol, pH7.2
Product Name Alternative
Catenin β; Cateninβ; Catenin beta-1; Beta-catenin; CTNNB1; CTNNB; ORF Names: OK/SW-cl.35; PRO2286
Swiss Prot
P35222
Reactivity
Human, Mouse, Rat
Immunogen
A phospho specific peptide corresponding to residues surrounding threonine 41 and 45 of Human Catenin-β.
Conjugation
Unconjugated
Related Pathways
Hypoxia Signaling, Wntβ catenin signaling, Contribution of ECM and Cytoskeletal Factors to EMT, Contribution of Soluble Factors to EMT, hippo Signaling, Adherens Junction signaling
Applications
IHC
Dilution
IHC: 1:50~1:200
Purity
The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen and the purity is > 95% (by SDS-PAGE) .
Modification
Phosphorylation
Molecular Weight
~ 92 kDa
Storage Conditions
Store at 4°C short term. Aliquot and store at -20°C long term. Avoid freeze-thaw cycles.
Notes
For research use only, not for use in diagnostic procedure.
Specificity
P-beta-catenin (T41/S45) polyclonal antibody detects endogenous levels of beta-catenin protein only when phosphorylated at Thr41/S45.
Host or Source
Rabbit
Available Sizes
Frequently Asked Questions
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