STAM2 (phospho-Y192) polyclonal antibody
Product Specifications
Background
STAM contains an SH3 (Src homology 3) motif as well as an immunoreceptor tyrosine-based activation (ITAM) motif, both of which appear to be required for c-Myc induction in response to IL-2 and GM-CSF. STAM associates with JAK3 and JAK2 via its ITAM region, and it is tyrosine phosphorylated by JAK3 and JAK2 after stimulation with IL-2 and GM-CSF, respectively. STAM2, also known as Hbp, is a protein that is highly related to STAM. Similar to STAM, STAM2 functions downstream of JAK kinases and can be phosphorylated in response to cytokines. Due to alternative splicing events, two isoforms of STAM2 exist, namely STAM2A and STAM2B.
CAS Number
9007-83-4
Structure Composition
Rabbit IgG, 1mg/ml in PBS with 0.02% sodium azide, 50% glycerol, pH7.2
Product Name Alternative
Signal transducing adapter molecule 2; STAM-2; Hrs-binding protein; STAM2; HBP
Swiss Prot
O75886
Reactivity
Human, Mouse, Rat
Immunogen
Synthetic phosphopeptide derived from human STAM2 around the phosphorylation site of Tyrosine 192.
Conjugation
Unconjugated
Applications
WB
Dilution
WB: 1:500~1:1000
Purity
The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen and the purity is > 95% (by SDS-PAGE) .
Modification
Phosphorylation
Molecular Weight
~ 58 kDa
Storage Conditions
Store at 4°C short term. Aliquot and store at -20°C long term. Avoid freeze-thaw cycles.
Notes
For research use only, not for use in diagnostic procedure.
Specificity
P-STAM2 (Y192) polyclonal antibody detects endogenous levels of STAM2 protein only when phosphorylated at Tyr192.
Applications Notes
Western blot (WB) analysis of p-STAM2 (Y192) polyclonal antibody at 1:500 dilution Lane1:HEK293T cell treated with EGF (0.1ng/ML,30min) Lane2:sp2/0 cell treated with EGF (0.1ng/ML,30min) Lane3:Rat spleen tissue lysate
Host or Source
Rabbit
Available Sizes
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