VASP (phospho-S238) polyclonal antibody
Product Specifications
Background
VASP (vasodilator-stimulated phosphoprotein), is involved in the maintenance of cytoarchitecture by interacting with actin-like filaments. VASP shares a limited degree of homology with the amino terminus of WASP, which is frequently mutated in WAS patients. An established substrate of cAMP and cGMP dependent kinases, VASP is phosphorylated on a regulatory serine residue 157 and localizes to focal adhesions, microfilaments and highly active regions of the plasma membrane. VASP is a protein of between 46 and 50 kDa that is highly expressed in human platelets and, like WASP, may play a role in cytoskeletal organization.
CAS Number
9007-83-4
Structure Composition
Rabbit IgG, 1mg/ml in PBS with 0.02% sodium azide, 50% glycerol, pH7.2
Product Name Alternative
Vasodilator-stimulated phosphoprotein; VASP
Swiss Prot
P50552
Reactivity
Human, Mouse, Rat
Immunogen
Synthetic phosphopeptide derived from human VASP around the phosphorylation site of Serine 238.
Conjugation
Unconjugated
Related Pathways
Regulation of Actin Dynamics
Applications
WB IHC
Dilution
WB: 1:500~1:1000 IHC: 1:50~1:200
Purity
The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen and the purity is > 95% (by SDS-PAGE) .
Modification
Phosphorylation
Molecular Weight
~ 40, 48 kDa
Storage Conditions
Store at 4°C short term. Aliquot and store at -20°C long term. Avoid freeze-thaw cycles.
Notes
For research use only, not for use in diagnostic procedure.
Specificity
P-VASP (S238) polyclonal antibody detects endogenous levels of VASP protein only when phosphorylated at Ser238.
Applications Notes
Western blot (WB) analysis of p-VASP (S238) polyclonal antibody at 1:500 dilution Lane1:Hela cell lysate treated with forskolin (10nM, 72h) Lane2:Raw264.7 cell lysate treated with forskolin (10nM, 72h) Lane3:PC12 cell lysate treated with forskolin (10nM, 72h)
Host or Source
Rabbit
Available Sizes
Curated Selection
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