JAK2 (phospho-Y570) polyclonal antibody
Product Specifications
Background
Jak2 (Janus Kinase 2) belongs to the emerging family of non-receptor janus tyrosine kinases, which regulate a spectrum of cellular functions downstream of activated cytokine receptors in the lympho-hematopoietic system. Immunological stimuli, such as interferons and cytokines, induce recruitment of STAT transcription factors to cytokine receptor-associated Jak2. Jak2 then phosphorylates proximal STAT factors, which subsequently dimerize, translocate to the nucleus and bind to cis elements upstream of target gene promoters to regulate transcription. The canonical Jak-STAT pathway is integral to maintaining a normal immune system by stimulating proliferation, differentiation, survival, and host resistance to pathogens. Altering Jak-STAT signaling to reduce cytokine induced pro-inflammatory responses represents an attractive target for anti-inflammatory therapies.
Structure Composition
Rabbit IgG, 1mg/ml in PBS with 0.02% sodium azide, 50% glycerol, pH7.2
Product Name Alternative
JAK 2; JAK-2; JAK2; Janus Activating Kinase 2; Janus Kinase 2; Janus Kinase 2; JTK 10; JTK10
Swiss Prot
O60674
Reactivity
Human, Mouse, Rat
Immunogen
Synthetic phosphopeptide derived from human JAK2 around the phosphorylation site of Tyrosine 570.
Conjugation
Unconjugated
Related Pathways
Jak Stat : IL-6 Receptor Signaling, Inhibition of Apoptosis
Applications
WB
Dilution
WB: 1:500~1:1000
Purity
The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen and the purity is > 95% (by SDS-PAGE) .
Modification
Phosphorylation
Molecular Weight
~ 125 kDa
Storage Conditions
Store at 4°C short term. Aliquot and store at -20°C long term. Avoid freeze-thaw cycles.
Notes
For research use only, not for use in diagnostic procedure.
Specificity
P-JAK2 (Y570) polyclonal antibody detects endogenous levels of JAK2 only when phosphorylated at Tyr570.
Applications Notes
Western blot (WB) analysis of p-JAK2 (Y570) polyclonal antibody at 1:500 dilution Lane1:Hela cell lysate Lane2:NIH-3T3 cell lysate Lane3:Rat kidney tissue lysate
Host or Source
Rabbit
CAS Number
9007-83-4
Available Sizes
Curated Selection
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