IL-13Rα1 (phospho-Y405) polyclonal antibody

Product Specifications

Background

The protein encoded by this gene is a subunit of the interleukin 13 receptor. This subunit forms a receptor complex with IL4 receptor alpha, a subunit shared by IL13 and IL4 receptors. This subunit serves as a primary IL13-binding subunit of the IL13 receptor, and may also be a component of IL4 receptors. This protein has been shown to bind tyrosine kinase TYK2, and thus may mediate the signaling processes that lead to the activation of JAK1, STAT3 and STAT6 induced by IL13 and IL4.

CAS Number

9007-83-4

Structure Composition

Rabbit IgG, 1mg/ml in PBS with 0.02% sodium azide, 50% glycerol, pH7.2

Product Name Alternative

Interleukin-13 receptor subunit alpha-1; IL-13 receptor subunit alpha-1; IL-13R subunit alpha-1; IL-13R-alpha-1; IL-13RA1; Cancer/testis antigen 19; CT19; CD213a1; IL13RA1; IL13R; IL13RA

Swiss Prot

P78552

Reactivity

Human, Mouse, Rat

Immunogen

Synthetic phosphopeptide derived from human IL-13Rα1 around the phosphorylation site of Tyrosine 405.

Conjugation

Unconjugated

Applications

Dilution

WB: 1:500~1:1000

Purity

The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen and the purity is > 95% (by SDS-PAGE) .

Modification

Phosphorylation

Molecular Weight

~ 49 kDa

Storage Conditions

Store at 4°C short term. Aliquot and store at -20°C long term. Avoid freeze-thaw cycles.

Notes

For research use only, not for use in diagnostic procedure.

Specificity

IL-13Rα1 (phospho-Y405) polyclonal antibody detects endogenous levels of IL-13Rα1 protein when phosphorylated at Tyr405.

Applications Notes

Western blot (WB) analysis of p-IL-13Rα1 (Y405) pAb at 1:500 dilution Lane1:SK-OVCAR3 whole cell lysate (40µg) Lane2:LO2 whole cell lysate (40µg) Lane3:RAW264.7 whole cell lysate (40µg) Lane4:C6 whole cell lysate (40µg)