PYK2 (phospho-Y580) polyclonal antibody

Product Specifications

Background

Pyk2 is a protein tyrosine kinase related to Focal Adhesion Kinase (p125 FAK) . Pyk2 is highly expressed in the central nervous system. It is phosphorylated on tyrosine residues in response to various stimuli that elevate intracellular calcium concentration, as well as by protein kinase C activation.

CAS Number

9007-83-4

Structure Composition

Rabbit IgG, 1mg/ml in PBS with 0.02% sodium azide, 50% glycerol, pH7.2

Product Name Alternative

Cell adhesion kinase beta; CAK beta; Calcium-dependent tyrosine kinase; CADTK; Related adhesion focal tyrosine kinase; RAFTK; PYK2; FAK2; PYK2; RAFTK

Swiss Prot

Q14289

Reactivity

Human, Mouse, Rat

Immunogen

Synthetic phosphopeptide derived from human PYK2 around the phosphorylation site of Tyrosine 580.

Conjugation

Unconjugated

Related Pathways

G Protein-coupled Receptors Signaling to MAPK Erk, Amyloid Plaque and Neurofibrillary Tangle Formation in Alzheimer's Disease

Applications

IHC

Dilution

IHC: 1:50~1:200

Purity

The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen and the purity is > 95% (by SDS-PAGE) .