APP/β-Amyloid (phospho-T668) polyclonal antibody

Proteolytic cleavage of the Amyloid protein precursor (APP) gives rise to the β-Amyloid and Amyloid A4 proteins, which are present in human platelets. Amyloid deposition is associated with type II diabetes, Down syndrome and a variety of neurological disorders, including Alzheimer’s disease. The Amyloid precursor protein (APP) undergoes alternative splicing, resulting in several isoforms. Proteolytic cleavage of APP leads to the formation of the Amyloid β/A4 Amyloid protein. This protein is involved in the formation of neurofibrillary tangles and plaques that characterize the senile plaques of Alzheimer’s patients. APLP1 (Amyloid precursor-like protein 1) and APLP2 are structurally similar to APP.

Amyloid beta A4 protein; ABPP; APPI; Short name=APP; Alzheimer disease amyloid protein; Cerebral vascular amyloid peptide; Short name=CVAP; PreA4; Protease nexin-II; Short name=PN-II; N-APP; Soluble APP-alpha; Short name=S-APP-alpha; Soluble APP-beta; Short name=S-APP-beta; Beta-amyloid protein 42; Beta-APP42; Beta-amyloid protein 40; Beta-APP40; P3 (42) ; P3 (40) ; Gamma-secretase C-terminal fragment 59; Amyloid intracellular domain 59; Short name=AICD-59; Short name=AID (59) ; Gamma-CTF (59) ; Gamma-secretase C-terminal fragment 57; Amyloid intracellular domain 57; Short name=AICD-57; Short name=AID (57) ; Gamma-CTF (57) ; Gamma-secretase C-terminal fragment 50; Amyloid intracellular domain 50; AICD-50; AID (50) ; Gamma-CTF (50) ; APP; A4; AD; Amyloid-β; Amyloid β; Amyloidβ; β Amyloid; βAmyloid; Aβ

The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen and the purity is > 95% (by SDS-PAGE) .

P-APP/β-Amyloid (T668) polyclonal antibody detects endogenous levels of APP695 protein only when phosphorylated at Thr668 (or the corresponding position on other isoforms) .

Western blot (WB) analysis of p-APP/β-Amyloid (T668) pAb at 1:500 dilution Lane1:The Kidney tissue lysate of Mouse (20ug) Lane2:The Uterus tissue lysate of Rat (20ug) Lane3:Panc1 whole cell lysate (20ug) Lane4:PC3 whole cell lysate (20ug)