APP/β-Amyloid (phospho-T668) polyclonal antibody
Product Specifications
Background
Proteolytic cleavage of the Amyloid protein precursor (APP) gives rise to the β-Amyloid and Amyloid A4 proteins, which are present in human platelets. Amyloid deposition is associated with type II diabetes, Down syndrome and a variety of neurological disorders, including Alzheimer’s disease. The Amyloid precursor protein (APP) undergoes alternative splicing, resulting in several isoforms. Proteolytic cleavage of APP leads to the formation of the Amyloid β/A4 Amyloid protein. This protein is involved in the formation of neurofibrillary tangles and plaques that characterize the senile plaques of Alzheimer’s patients. APLP1 (Amyloid precursor-like protein 1) and APLP2 are structurally similar to APP.
CAS Number
9007-83-4
Structure Composition
Rabbit IgG, 1mg/ml in PBS with 0.02% sodium azide, 50% glycerol, pH7.2
Product Name Alternative
Amyloid beta A4 protein; ABPP; APPI; Short name=APP; Alzheimer disease amyloid protein; Cerebral vascular amyloid peptide; Short name=CVAP; PreA4; Protease nexin-II; Short name=PN-II; N-APP; Soluble APP-alpha; Short name=S-APP-alpha; Soluble APP-beta; Short name=S-APP-beta; Beta-amyloid protein 42; Beta-APP42; Beta-amyloid protein 40; Beta-APP40; P3 (42) ; P3 (40) ; Gamma-secretase C-terminal fragment 59; Amyloid intracellular domain 59; Short name=AICD-59; Short name=AID (59) ; Gamma-CTF (59) ; Gamma-secretase C-terminal fragment 57; Amyloid intracellular domain 57; Short name=AICD-57; Short name=AID (57) ; Gamma-CTF (57) ; Gamma-secretase C-terminal fragment 50; Amyloid intracellular domain 50; AICD-50; AID (50) ; Gamma-CTF (50) ; APP; A4; AD; Amyloid-β; Amyloid β; Amyloidβ; β Amyloid; βAmyloid; Aβ
Swiss Prot
P05067
Reactivity
Human, Mouse, Rat
Immunogen
Synthetic phosphopeptide derived from human APP/β-Amyloid around the phosphorylation site of Threonine 668.
Conjugation
Unconjugated
Related Pathways
Neuronal and Glial Cell Marker Atlas, Amyloid Plaque and Neurofibrillary Tangle Formation in Alzheimer's Disease
Applications
WB IHC
Dilution
WB: 1:500~1:1000 IHC: 1:50~1:200
Purity
The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen and the purity is > 95% (by SDS-PAGE) .
Modification
Phosphorylation
Molecular Weight
~ 70 to140 kDa
Storage Conditions
Store at 4°C short term. Aliquot and store at -20°C long term. Avoid freeze-thaw cycles.
Notes
For research use only, not for use in diagnostic procedure.
Specificity
P-APP/β-Amyloid (T668) polyclonal antibody detects endogenous levels of APP695 protein only when phosphorylated at Thr668 (or the corresponding position on other isoforms) .
Applications Notes
Western blot (WB) analysis of p-APP/β-Amyloid (T668) pAb at 1:500 dilution Lane1:The Kidney tissue lysate of Mouse (20ug) Lane2:The Uterus tissue lysate of Rat (20ug) Lane3:Panc1 whole cell lysate (20ug) Lane4:PC3 whole cell lysate (20ug)
Host or Source
Rabbit
Available Sizes
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