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Stat5a/b (phospho-Y694) polyclonal antibody

Product Specifications

Background

Stat 5a protein is a transcription factor activated by hormone and cytokines. Two highly related, but distinct Stat 5 genes (Stat 5a and Stat 5b) were identified in mouse. The amino acid sequences of Stat 5a and Stat 5b show 96% sequence similarity, and both proteins are co expressed in most tissues of both virgin and lactating mice. However, differential accumulation of Stat 5a and Stat 5b mRNA has been reported for both muscle and mammary tissue. Stat 5a is critically involved in a variety of physiological functions, including reproduction, lactation, immune function and somatic growth.

CAS Number

9007-83-4

Structure Composition

Rabbit IgG, 1mg/ml in PBS with 0.02% sodium azide, 50% glycerol, pH7.2

Product Name Alternative

Signal transducer and activator of transcription 5A; STAT5A; STAT5; Signal transducer and activator of transcription 5B; STAT5B

Swiss Prot

P42229/P51692

Reactivity

Human, Mouse, Rat

Immunogen

Synthetic phosphopeptide derived from human Stat5a around the phosphorylation site of Tyrosine 694.

Conjugation

Unconjugated

Related Pathways

Immune Cell Signaling, Jak Stat : IL-6 Receptor Signaling, T cell receptor signaling

Applications

IHC

Dilution

IHC: 1:50~1:200

Purity

The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen and the purity is > 95% (by SDS-PAGE) .

Modification

Phosphorylation

Molecular Weight

~ 90 kDa

Storage Conditions

Store at 4°C short term. Aliquot and store at -20°C long term. Avoid freeze-thaw cycles.

Notes

For research use only, not for use in diagnostic procedure.

Specificity

P-Stat5a/b (Y694) polyclonal antibody detects endogenous levels of Stat5a/b protein only when phosphorylated at Tyr694

Host or Source

Rabbit

Available Sizes

Frequently Asked Questions

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