NFkB-p65 (phospho-S468) polyclonal antibody

Product Specifications

Background

P65 is a subunit of the nuclear factor kappa B. The transcription factor NFkB is widely recognized as a critical mediator of immune and inflammatory responses. In most cell types, NFkB is found in the cytoplasm where it is associated with an inhibitory prd in many tissues. A high proportion of spontaneous NIH/3T3 transformants overexpress c-Met and by transfection analysis the c-Met proto-oncogene has been shown to exhibittransforming activity.

CAS Number

9007-83-4

Structure Composition

Rabbit IgG, 1mg/ml in PBS with 0.02% sodium azide, 50% glycerol, pH7.2

Product Name Alternative

P65; p65 NF kappaB; p65 NFkB; RELA; NFKB P65; Transcription Factor p65; Nuclear factor NF-kappa-B p65 subunit; NFkB-p65; NFKB3

Swiss Prot

Q04206

Reactivity

Human, Mouse, Rat

Immunogen

Synthetic phosphopeptide derived from human NFkB-p65 around the phosphorylation site of Serine 468.

Conjugation

Unconjugated

Related Pathways

NF-kB Signaling, NF-kB Signaling, Immune Cell Signaling, Signaling Pathways Activating p38 MAP KinaseSTING Signaling, T cell receptor signaling, Inhibition of Apoptosis, Contribution of Soluble Factors to EMT

Applications

IHC IP

Dilution

IHC: 1:50~1:200 IP: 1:50~1:200

Purity

The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen and the purity is > 95% (by SDS-PAGE) .