NFkB-p65 (phospho-S468) polyclonal antibody
Product Specifications
Background
P65 is a subunit of the nuclear factor kappa B. The transcription factor NFkB is widely recognized as a critical mediator of immune and inflammatory responses. In most cell types, NFkB is found in the cytoplasm where it is associated with an inhibitory prd in many tissues. A high proportion of spontaneous NIH/3T3 transformants overexpress c-Met and by transfection analysis the c-Met proto-oncogene has been shown to exhibittransforming activity.
CAS Number
9007-83-4
Structure Composition
Rabbit IgG, 1mg/ml in PBS with 0.02% sodium azide, 50% glycerol, pH7.2
Product Name Alternative
P65; p65 NF kappaB; p65 NFkB; RELA; NFKB P65; Transcription Factor p65; Nuclear factor NF-kappa-B p65 subunit; NFkB-p65; NFKB3
Swiss Prot
Q04206
Reactivity
Human, Mouse, Rat
Immunogen
Synthetic phosphopeptide derived from human NFkB-p65 around the phosphorylation site of Serine 468.
Conjugation
Unconjugated
Related Pathways
NF-kB Signaling, NF-kB Signaling, Immune Cell Signaling, Signaling Pathways Activating p38 MAP KinaseSTING Signaling, T cell receptor signaling, Inhibition of Apoptosis, Contribution of Soluble Factors to EMT
Applications
IHC IP
Dilution
IHC: 1:50~1:200 IP: 1:50~1:200
Purity
The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen and the purity is > 95% (by SDS-PAGE) .
Modification
Phosphorylation
Molecular Weight
~ 60, 75 kDa
Storage Conditions
Store at 4°C short term. Aliquot and store at -20°C long term. Avoid freeze-thaw cycles.
Notes
For research use only, not for use in diagnostic procedure.
Specificity
P-NFκB-p65 (S468) polyclonal antibody detects endogenous levels of NFκB-p65 protein when phosphorylated at Ser468.
Host or Source
Rabbit
Available Sizes
Curated Selection
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