G3BP-1 (phospho-S232) polyclonal antibody

Product Specifications

Background

G3BP is one of the DNA-unwinding enzymes which prefers partially unwound 3'-tailed substrates and can also unwind partial RNA/DNA and RNA/RNA duplexes in an ATP-dependent fashion. This enzyme is a member of the heterogeneous nuclear RNA-binding proteins and is also an element of the Ras signal transduction pathway. It binds specifically to the Ras-GTPase-activating protein by associating with its SH3 domain. Several alternatively spliced transcript variants of this gene have been described, but the full-length nature of some of these variants has not been determined.

CAS Number

9007-83-4

Structure Composition

Rabbit IgG, 1mg/ml in PBS with 0.02% sodium azide, 50% glycerol, pH7.2

Product Name Alternative

G3BP1; G3BP; hDH VIII; G3BP-1; Ras GTPase-activating protein-binding protein 1; GAP SH3 domain-binding protein 1

Swiss Prot

Q13283

Reactivity

Human, Mouse, Rat

Immunogen

Synthetic phosphopeptide derived from human G3BP-1 around the phosphorylation site of Serine 232.

Conjugation

Unconjugated

Applications

IHC

Dilution

IHC: 1:50~1:200

Purity

The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen and the purity is > 95% (by SDS-PAGE) .