Cdk2 (phospho-T160) polyclonal antibody
Product Specifications
Background
Cdk2 is a member of the Ser/Thr protein kinase family. It is highly similar to the gene products of S. cerevisiae cdc28, and S. pombe cdc2. It is a catalytic subunit of the cyclin-dependent protein kinase complex, whose activity is restricted to the G1-S phase, and is essential for cell cycle G1/S phase transition. This protein associates with and is regulated by the regulatory subunits of the complex including cyclin A or E, CDK inhibitor p21Cip1 (CDKN1A) and p27Kip1 (CDKN1B) . Its activity is also regulated by protein phosphorylation. Two alternatively spliced variants and multiple transcription initiation sites of this gene have been reported.
CAS Number
9007-83-4
Structure Composition
Rabbit IgG, 1mg/ml in PBS with 0.02% sodium azide, 50% glycerol, pH7.2
Product Name Alternative
Cyclin-dependent kinase 2; Cell division protein kinase 2; p33 protein kinase; CDK2; CDKN2
Swiss Prot
P24941
Reactivity
Human, Mouse, Rat
Immunogen
Synthetic phosphopeptide derived from human Cdk2 around the phosphorylation site of Threonine 160.
Conjugation
Unconjugated
Related Pathways
Cell Cycle Control G1 S Checkpoint, Cell Cycle G2 M DNA Damage Signaling Pathway
Applications
IHC
Dilution
IHC: 1:50~1:200
Purity
The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen and the purity is > 95% (by SDS-PAGE) .
Modification
Phosphorylation
Molecular Weight
~ 34 kDa
Storage Conditions
Store at 4°C short term. Aliquot and store at -20°C long term. Avoid freeze-thaw cycles.
Notes
For research use only, not for use in diagnostic procedure.
Specificity
P-CDK2 (T160) polyclonal antibody detects endogenous levels of CDK2 protein only when phosphorylated at Thr160.
Host or Source
Rabbit
Available Sizes
Frequently Asked Questions
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