AR (phospho-S213) polyclonal antibody

Product Specifications

Background

Androgens exhibit a wide range of effects on the development, maintenance and regulation of male phenotype and reproductive physiology in males. The androgen receptor (AR) is a member of the steroid superfamily of ligand-dependent transcription factors. ARs bind active testosterone (T) and dihydrotestosterone (DHT) . The rates of association and dissociation of T are about 3 times more rapid than those of DHT. This difference in binding kinetics may account for the different physiological effects of T and DHT. Androgen binding results in an at least 6-fold increase in androgen receptor stability.

CAS Number

9007-83-4

Structure Composition

Rabbit IgG, 1mg/ml in PBS with 0.02% sodium azide, 50% glycerol, pH7.2

Product Name Alternative

Androgen receptor; Dihydrotestosterone receptor; Nuclear receptor subfamily 3 group C member 4; AR; DHTR; NR3C4

Swiss Prot

P10275

Reactivity

Human

Immunogen

Synthetic phosphopeptide derived from human AR around the phosphorylation site of Serine 213.

Conjugation

Unconjugated

Related Pathways

Nuclear Receptor Signaling

Applications

IHC

Dilution

IHC: 1:50~1:200

Purity

The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen and the purity is > 95% (by SDS-PAGE) .