CEP290 (F812) polyclonal antibody
Product Specifications
Background
CEP290 activates ATF4 mediated transcription and is required for the correct localization of ciliary and phototransduction proteins in retinal photoreceptor cells; may play a role in ciliary transport processes. CEP290 is ubiquitously expressed; strongly in placenta and weakly in brain. There are two named isoforms. Defects in CEP290 are a cause of Joubert syndrome type 5 (JBTS5), Senior-Loken syndrome type 6 (SLSN6), Leber congenital amaurosis type 10 (LCA10) and Meckel syndrome type 4 (MKS4) . Antibodies against CEP290 are present in sera from patients with cutaneous T cell lymphomas, but not in the healthy control population.
CAS Number
9007-83-4
Structure Composition
Rabbit IgG, 1mg/ml in PBS with 0.02% sodium azide, 50% glycerol, pH7.2
Product Name Alternative
Centrosomal protein of 290 kDa; Cep290; Bardet-Biedl syndrome 14 protein; Cancer/testis antigen 87; CT87; Nephrocystin-6; Tumor antigen se2-2; CEP290; BBS14; KIAA0373; NPHP6
Swiss Prot
O15078
Reactivity
Human, Mouse, Rat
Immunogen
Synthetic peptide, corresponding to amino acids 781-830 of Human CEP290.
Conjugation
Unconjugated
Applications
WB
Dilution
WB: 1:500~1:1000
Purity
The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen and the purity is > 95% (by SDS-PAGE) .
Modification
Unmodification
Molecular Weight
~ 290 kDa
Storage Conditions
Store at 4°C short term. Aliquot and store at -20°C long term. Avoid freeze-thaw cycles.
Notes
For research use only, not for use in diagnostic procedure.
Specificity
CEP290 (F812) polyclonal antibody detects endogenous levels of CEP290 protein.
Applications Notes
Western blot (WB) analysis of CEP290 (F812) polyclonal antibody at 1:500 dilution Lane1:HCT116 whole cell lysate (40ug) Lane2:SGC7901 whole cell lysate (40ug) Lane3:COS-7 whole cell lysate (40ug) Lane4:A549 whole cell lysate (40ug) Lane5:CT26 whole cell lysate (40ug) Lane6:AML-12 whole cell lysate (40ug) Lane7:PC12 whole cell lysate (40ug)
Host or Source
Rabbit
Available Sizes
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