SLC25A6 (R155) polyclonal antibody

Product Specifications

Background

ANT2 (adenine nucleotide translocator 2), also known as SLC25A5 (solute carrier family 25 (mitochondrial carrier; adenine nucleotide translocator), member 5), T2, T3, 2F1 or AAC2, is a 298 amino acid multi-pass membrane protein that localizes to the inner mitochondrial membrane and contains three solcar repeats. Existing as one of the most abundant mitochondrial proteins, ANT2 functions as a homodimer that facilitates the exchange of ADP and ATP between the mitochondrion and the cytosol, thus linking the compartment of ATP production (within the mitochondrion) to the areas of ATP utilization (within the cytosol) . Suppression of ANT2 in breast cancer cells results in apoptosis and tumor growth inhibition, suggesting that ANT2 may be involved in carcinogenesis. ANT3 (adenine nucleotide translocator 2) is a 298 amino acid mitochondrial protein that functions in a similar manner to ANT2 but, unlike ANT2, may also play a role in the formation of the permeability transition pore complex (PTPC), a structure that is important for the regulation of apoptosis.

CAS Number

9007-83-4

Structure Composition

Rabbit IgG, 1mg/ml in PBS with 0.02% sodium azide, 50% glycerol, pH7.2

Product Name Alternative

ADP/ATP translocase 3; ADP, ATP carrier protein 3; ADP, ATP carrier protein, isoform T2; ANT 2; Adenine nucleotide translocator 3; ANT 3; Solute carrier family 25 member 6; SLC25A6; ANT3; ORF Names: CDABP0051

Swiss Prot

P12236

Reactivity

Human, Mouse, Rat

Immunogen

Synthetic peptide, corresponding to amino acids 120-160 of Human SLC25A6.

Conjugation

Unconjugated

Applications

WB IHC

Dilution

WB: 1:500~1:1000 IHC: 1:50~1:200

Purity

The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen and the purity is > 95% (by SDS-PAGE) .

Modification

Unmodification

Molecular Weight

~ 33 kDa

Storage Conditions

Store at 4°C short term. Aliquot and store at -20°C long term. Avoid freeze-thaw cycles.

Notes

For research use only, not for use in diagnostic procedure.

Specificity

SLC25A6 (R155) polyclonal antibody detects endogenous levels of SLC25A6 protein.

Applications Notes

Western blot (WB) analysis of SLC25A6 (R155) pAb at 1:1000 dilution Lane1:H1792 whole cell lysate (40ug) Lane2:HepG2 whole cell lysate (40ug) Lane3:The Testis tissue lysate of Mouse (40ug) Lane4:The Testis tissue lysate of Rat (40ug) Lane5:HEK293T whole cell lysate (20ug)