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EphB1/2/3/4 (Y594) polyclonal antibody

Product Specifications

Background

Ephrin receptors bind members of the ephrin ligand family. They are divided into 2 groups based on the similarity of their extracellular domain sequences and their affinities for binding ephrin-A and ephrin-B ligands. They make up the largest subgroup of the receptor tyrosine kinase (RTK) family. Eph receptor B1 (EphB1) and Eph receptor B2 (EphB2) are receptors for ephrin-B family members. Developing and adult neural tissue express nearly all of the Ephrin receptors and ephrin ligands. Ephrins and ephrin receptors also play a significant role in angiogenesis. EphB2 acts as a tumor suppressor.

CAS Number

9007-83-4

Structure Composition

Rabbit IgG, 1mg/ml in PBS with 0.02% sodium azide, 50% glycerol, pH7.2

Product Name Alternative

EphB1; EphB2; EphB3; EphB4

Swiss Prot

P54762/P29323/P54753/P54760

Reactivity

Human, Mouse

Immunogen

Synthetic peptide, corresponding to amino acids 560-610 of Human EphB1.

Conjugation

Unconjugated

Related Pathways

Tumor Angiogenesis, Tumor Angiogenesis

Applications

IHC

Dilution

IHC: 1:50~1:200

Purity

The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen and the purity is > 95% (by SDS-PAGE) .

Modification

Unmodification

Molecular Weight

~ 118 kDa

Storage Conditions

Store at 4°C short term. Aliquot and store at -20°C long term. Avoid freeze-thaw cycles.

Notes

For research use only, not for use in diagnostic procedure.

Specificity

EphB1/2/3/4 (Y594) polyclonal antibody detects endogenous levels of EphB1/2/3/4 protein.

Host or Source

Rabbit

Available Sizes

Frequently Asked Questions

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