NCAM-L1 (R1177) polyclonal antibody

Product Specifications

Background

The L1CAM gene, which is located in Xq28, is involved in three distinct conditions: 1) HSAS (hydrocephalus-stenosis of the aqueduct of Sylvius) ; 2) MASA (mental retardation, aphasia, shuffling gait, adductus thumbs) ; and 3) SPG1 (spastic paraplegia) . The L1, neural cell adhesion molecule (L1CAM) also plays an important role in axon growth, fasciculation, neural migration and in mediating neuronal differentiation. Expression of L1 protein is restricted to tissues arising from neuroectoderm.

CAS Number

9007-83-4

Structure Composition

Rabbit IgG, 1mg/ml in PBS with 0.02% sodium azide, 50% glycerol, pH7.2

Product Name Alternative

MIC 5; antigen identified by monoclonal antibody R1; MASA; CD 171; MIC5; N CAML1; SPG1; N CAM L1; HSAS; CD171; CD171 antigen; SPG 1; L1 cell adhesion molecule; HSAS1; HGNC:7086; NEURAL CELL ADHESION MOLECULE L1 PRECURSOR; S10; CAML1

Swiss Prot

P32004

Reactivity

Human, Mouse, Rat

Immunogen

Synthetic peptide, corresponding to amino acids 1150-1200 of Human NCAM-L1.

Conjugation

Unconjugated

Applications

WB IHC IF

Dilution

WB: 1:500~1:1000 IHC: 1:50~1:200 IF: 1:50~1:200

Purity

The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen and the purity is > 95% (by SDS-PAGE) .