Integrin β3 (S778) polyclonal antibody

Integrins are heterodimers composed of noncovalently associated transmembrane α and β subunits. The 16α and 8β subunits heterodimerize to produce more than 20 different receptors. Most Integrin receptors bind ligands that are components of the extracellular matrix, including Fibronectin, Collagen and Vitronectin. Certain Integrins can also bind to soluble ligands such as Fibrinogen, or to counterreceptors on adjacent cells such as the intracellular adhesion molecules (ICAMs), leading to aggregation of cells. Ligands serve to cross-link or cluster Integrins by binding to adjacent Integrin receptors; both receptor clustering and ligand occupancy are necessary for the activation of Integrinmediated responses.

The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen and the purity is > 95% (by SDS-PAGE) .

Western blot (WB) analysis of Integrin β3 (S778) pAb at 1:500 dilution Lane1:BV2 whole cell lysate (40ug) Lane2:RAW264.7 whole cell lysate (40ug) Lane3:The Uterus tissue lysate of Rat (40ug) Lane4:THP-1 whole cell lysate (40ug) Lane5:A549 whole cell lysate (40ug) Lane6:PC3 whole cell lysate (40ug) Lane7:U-87MG whole cell lysate (40ug)