Cathepsin B (N217) polyclonal antibody
Product Specifications
Background
The cathepsin family of proteolytic enzymes contains several diverse classes of proteases. The cysteine protease class comprises cathepsins B, L, H, K, S, and O. The aspartyl protease class is composed of cathepsins D and E. Cathepsin G is in the serine protease class. Most cathepsins are lysosomal and each is involved in cellular metabolism, participating in various events such as peptide biosynthesis and protein degradation. Cathepsin B is expressed in luminal epithelial cells, indicating that cathepsin B is a marker for secretory cell death.
CAS Number
9007-83-4
Structure Composition
Rabbit IgG, 1mg/ml in PBS with 0.02% sodium azide, 50% glycerol, pH7.2
Product Name Alternative
Cathepsin B; APP secretase; APPS; Cathepsin B1; CTSB; CPSB
Swiss Prot
P07858
Reactivity
Human, Mouse, Rat
Immunogen
Synthetic peptide, corresponding to amino acids 181-230 of Human Cathepsin B.
Conjugation
Unconjugated
Related Pathways
Amyloid Plaque and Neurofibrillary Tangle Formation in Alzheimer's Disease
Applications
WB IHC
Dilution
WB: 1:500~1:1000 IHC: 1:50~1:200
Purity
The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen and the purity is > 95% (by SDS-PAGE) .
Modification
Unmodification
Molecular Weight
~ 36 kDa
Storage Conditions
Store at 4°C short term. Aliquot and store at -20°C long term. Avoid freeze-thaw cycles.
Notes
For research use only, not for use in diagnostic procedure.
Specificity
Cathepsin B (N217) polyclonal antibody detects endogenous levels of Cathepsin B protein.
Applications Notes
Western blot (WB) analysis of Cathepsin B (N217) pAb at 1:2000 dilution Lane1:The Embryo tissue lysate of Mouse (40ug) Lane2:The Lung tissue lysate of Rat (40ug) Lane3:HCT116 whole cell lysate (40ug) Lane4:A549 whole cell lysate (40ug)
Host or Source
Rabbit
Available Sizes
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