Connexin 32 (L115) polyclonal antibody
Product Specifications
Background
Each of the approximately 20 connexin isoforms produces channels with distinct permeabilities and electrical and chemical sensitivities; therefore, one connexin usually cannot fully substitute for another. Consequently, a wide variety of malignant phenotypes associate with decreased connexin expression and gap junction communication, dependent on the particular connexin that is effected. For instance, mutations in connexin 32 result in Charcot-Marie-Tooth disease, a demyelinating disease of the peripheral nervous system.
CAS Number
9007-83-4
Structure Composition
Rabbit IgG, 1mg/ml in PBS with 0.02% sodium azide, 50% glycerol, pH7.2
Product Name Alternative
Gap junction beta-1 protein; Connexin-32; Cx32; GAP junction 28 kDa liver protein; CX32; GJB1
Swiss Prot
P08034
Reactivity
Human, Mouse, Rat
Immunogen
Synthetic peptide, corresponding to amino acids 81-130 of Human Connexin 32.
Conjugation
Unconjugated
Applications
IHC
Dilution
IHC:1:50~1:200
Purity
The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen and the purity is > 95% (by SDS-PAGE) .
Modification
Unmodification
Molecular Weight
~ 32 kDa
Storage Conditions
Store at 4°C short term. Aliquot and store at -20°C long term. Avoid freeze-thaw cycles.
Notes
For research use only, not for use in diagnostic procedure.
Specificity
Connexin-32 (L115) polyclonal antibody detects endogenous levels of Connexin-32 protein.
Host or Source
Rabbit
Available Sizes
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