NCoA-3 (S587) polyclonal antibody

Several related transcriptional coactivators and corepressors have been described that work in concert with the steroid receptor family to either induce or repress transcription from hormone-responsive elements. This family includes GRIP1 (for GR interacting protein 1), also designated NCoA-2 or TIF-2; SRC-1 (for steroid receptor coactivator-1), also designated NCoA-1; and NCoA-3, also designated RAC3, ACTR, AIB-1 (for amplified in breast cancer) and p/CIP (for p300/CBP/co-integrator protein), which displays elevated expression in estrogen receptor positive ovarian and breast cancers and is required for the transcriptional activation of p300/CBP-dependent transcription factors.

Nuclear receptor coactivator 3; NCoA-3; EC=2.3.1.48; ACTR; Amplified in breast cancer 1 protein; AIB-1; CBP-interacting protein; pCIP; Class E basic helix-loop-helix protein 42; bHLHe42; Receptor-associated coactivator 3; RAC-3; Steroid receptor coactivator protein 3; SRC-3; Thyroid hormone receptor activator molecule 1; TRAM-1; AIB1; BHLHE42; RAC3; TRAM1; NCOA3

The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen and the purity is > 95% (by SDS-PAGE) .

Western blot (WB) analysis of NCoA-3 (S587) pAb at 1:500 dilution Lane1:H9C2 whole cell lysate (40ug) Lane2:AML-12 whole cell lysate (40ug) Lane3:L02 whole cell lysate (40ug) Lane4:Panc1 whole cell lysate (40ug) Lane5:MCF-7 whole cell lysate (40ug)