IL-20 (D61) polyclonal antibody
Product Specifications
Background
IL-20 is a member of the IL-10 family of cytokines that has been shown to be upregulated in psoriatic skin. The receptor for IL-20 (IL-20R) exists as a dimer consisting of IL-20Rα and IL-20Rβ. IL-20R also functions as a receptor for IL-19, IL-24 and IL-26. It is highly expressed in skin, brain and testis. IL-20, IL-20Rα and IL-20Rβ all have higher expression levels in psoriatic lesional (LS) skin than in nonlesional (NL) skin, suggesting a role for these proteins as potential therapeutic targets. IL-20 can induce signal transducer and activator of transcription (Stat) activation through IL-20R.
CAS Number
9007-83-4
Structure Composition
Rabbit IgG, 1mg/ml in PBS with 0.02% sodium azide, 50% glycerol, pH7.2
Product Name Alternative
Interleukin-20; Short name=IL-20; Cytokine Zcyto10; IL20; ZCYTO10; UNQ852/PRO1801
Swiss Prot
Q9NYY1
Reactivity
Human, Mouse, Rat
Immunogen
Synthetic peptide, corresponding to amino acids 30-78 of Human IL-20.
Conjugation
Unconjugated
Applications
WB IHC
Dilution
WB: 1:500~1:1000 IHC: 1:50~1:200
Purity
The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen and the purity is > 95% (by SDS-PAGE) .
Modification
Unmodification
Molecular Weight
~ 28 kDa
Storage Conditions
Store at 4°C short term. Aliquot and store at -20°C long term. Avoid freeze-thaw cycles.
Notes
For research use only, not for use in diagnostic procedure.
Specificity
IL-20 (D61) polyclonal antibody detects endogenous levels of IL-20 protein.
Applications Notes
Western blot (WB) analysis of IL20 pAb at 1:500 dilution Lane1:A375 whole cell lysate (40ug) Lane2:PC3 whole cell lysate (40ug) Lane3:MCF-7 whole cell lysate (40ug) Lane4:PMVEC whole cell lysate (40ug) Lane5:3T3-L1 whole cell lysate (40ug)
Host or Source
Rabbit
Available Sizes
Curated Selection
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